Pregnancy SmartSite^TM

Low blood sodium

Hyponatremia; Dilutional hyponatremia; Euvolemic hyponatremia; Hypervolemic hyponatremia; Hypovolemic hyponatremia

Definition

Low blood sodium is a condition in which the sodium level in the blood is lower than normal. The medical name of this condition is hyponatremia.

Causes

Sodium is found mostly in the body fluids outside the cells. Sodium is an electrolyte (mineral). It is very important for maintaining blood pressure. Sodium is also needed for nerves, muscles, and other body tissues to work properly.

When the amount of sodium in fluids outside cells drops below normal, water moves into the cells. This causes the cells to swell with too much water. Brain cells are especially sensitive to swelling, and this causes many of the symptoms of low blood sodium.

With hyponatremia, the imbalance of water to sodium is caused by one of three conditions:

Euvolemic hyponatremia -- total body water increases, but the body's sodium content stays the same
Hypervolemic hyponatremia -- both sodium and water content in the body increase, but the water gain is greater
Hypovolemic hyponatremia -- water and sodium are both lost from the body, but the sodium loss is greater

Low blood sodium can be caused by:

Burns that affect a large area of the body
Diarrhea
Diuretic medicines (water pills), which increase urine output and loss of sodium through the urine
Heart failure
Kidney diseases
Cirrhosis (advanced liver disease)
Syndrome of inappropriate antidiuretic hormone secretion (SIADH)
Sweating
Vomiting

Symptoms

Common symptoms include:

Confusion, irritability, restlessness
Convulsions
Fatigue
Headache
Loss of appetite
Muscle weakness, spasms, or cramps
Nausea, vomiting

Exams and Tests

Your health care provider will perform a complete physical examination and ask about your symptoms. Blood and urine tests will be done.

Lab tests that can confirm and help diagnose low sodium include:

Comprehensive metabolic panel (includes blood sodium, normal range is 135 to 145 mEq/L, or 135 to 145 mmol/L)
Blood osmolality
Urine osmolality
Urine sodium (normal level is 20 mEq/L in a random urine sample, and 40 to 220 mEq per day for a 24-hour urine test)

Treatment

The cause of low blood sodium must be diagnosed and treated. If cancer is the cause of the condition, then radiation, chemotherapy, or surgery to remove the tumor may correct the sodium imbalance.

Other treatments depend on the specific type of hyponatremia.

Treatments may include:

Fluids through a vein (IV)
Medicines to relieve symptoms
Limiting water intake

Outlook (Prognosis)

Outcome depends on the condition that is causing the problem. Hyponatremia that occurs in less than 48 hours (acute hyponatremia), is more dangerous than hyponatremia that develops slowly over time. When blood sodium level falls slowly over days or weeks (chronic hyponatremia), the brain cells have time to adjust and swelling may be minimal.

Possible Complications

In severe cases, low blood sodium can lead to:

Decreased consciousness, hallucinations or coma
Brain herniation
Death

When to Contact a Medical Professional

When your body's sodium level drops too much, it can be a life-threatening emergency. Call your provider right away if you have symptoms of this condition.

Prevention

Treating the condition that is causing hyponatremia can help.

If you play sports or do other vigorous activity, drink fluids such as sports drinks that contain electrolytes to keep your body's sodium level in a healthy range.

References

Dell KM. Fluid, electrolytes, and acid-base homeostasis. In: Martin RJ, Fanaroff AA, Walsh MC, eds. Fanaroff and Martin's Neonatal-Perinatal Medicine. 11th ed. Philadelphia, PA: Elsevier; 2020:chap 92.

Pasco J. Electrolyte disturbances. In: Cameron P, Little M, Mitra B, Deasy C, eds. Textbook of Adult Emergency Medicine. 5th ed. Philadelphia, PA: Elsevier; 2020:chap 12.2

Verbalis JG. Disorders of water balance. In: Yu ASL, Chertow GM, Luyckx VA, Marsden PA, Skorecki K, Taal MW, eds. Brenner and Rector's The Kidney. 11th ed. Philadelphia, PA: Elsevier; 2020:chap 15.

Schedule An Appointment

Review Date: 6/12/2023

Reviewed By: Jacob Berman, MD, MPH, Clinical Assistant Professor of Medicine, Division of General Internal Medicine, University of Washington School of Medicine, Seattle, WA. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. No warranty of any kind, either expressed or implied, is made as to the accuracy, reliability, timeliness, or correctness of any translations made by a third-party service of the information provided herein into any other language. © 1997- A.D.A.M., a business unit of Ebix, Inc. Any duplication or distribution of the information contained herein is strictly prohibited.