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Chronic inflammatory demyelinating polyneuropathy

Central nervous sy...Central nervous system and peripheral nervous system

Chronic inflammatory demyelinating polyradiculoneuropathy; Polyneuropathy - chronic inflammatory; CIDP; Chronic inflammatory polyneuropathy; Guillain-Barré - CIDP

Definition

Chronic inflammatory demyelinating polyneuropathy (CIDP) is a disorder that involves nerve swelling and irritation (inflammation) that leads to a loss of strength or sensation.

Causes

CIDP is one cause of damage to nerves outside the brain or spinal cord (peripheral neuropathy). Polyneuropathy means several nerves are involved. CIDP often affects both sides of the body.

CIDP is caused by an abnormal immune response. CIDP occurs when the immune system attacks the myelin cover of the nerves. For this reason, CIDP is thought to be an autoimmune disease.

Health care providers also consider CIDP as the chronic form of Guillain-Barré syndrome.

The specific triggers of CIDP vary. In many cases, the cause cannot be identified.

CIDP may occur with other conditions, such as:

Chronic hepatitis
Diabetes
Infection with the bacterium Campylobacter jejuni
HIV/AIDS
Immune system disorders due to cancer
Inflammatory bowel disease
Systemic lupus erythematosus
Cancer of the lymph system
Overactive thyroid
Side effects of medicines to treat cancer or HIV

Symptoms

Symptoms include any of the following:

Problems walking due to weakness or lack of feeling in the feet
Trouble using the arms and hands or legs and feet due to weakness
Sensation changes, such as numbness or decreased sensation, pain, burning, tingling, or other abnormal sensations (usually affects the feet first, then the arms and hands)

Other symptoms that can occur with CIDP include:

Abnormal or uncoordinated movement
Problems breathing
Fatigue
Hoarseness or changing voice or slurred speech

Exams and Tests

The provider will perform a physical exam and ask about the symptoms, focusing on the nervous system and muscles.

Tests that may be ordered include:

Electromyography (EMG) to check the muscles and the nerves that control the muscles
Nerve conduction tests to check how fast electrical signals move through a nerve
Nerve biopsy to remove a small piece of a nerve for examination
Spinal tap (lumbar puncture) to check the fluid that surrounds the brain and spinal cord
Blood tests may be done to look for specific proteins that are causing the immune attack on the nerves
Lung function tests to check if breathing is affected

Depending on the suspected cause of CIDP, other tests, such as x-rays, imaging scans, and blood tests, may be done.

Treatment

The goal of treatment is to reverse the attack on the nerves. In some cases, nerves can heal and their function can be restored. In other cases, nerves are badly damaged and cannot heal, so treatment is aimed at preventing the disease from getting worse.

Which treatment is given depends on how severe the symptoms are, among other things. The most aggressive treatment is only given if you have difficulty walking, breathing, or if symptoms don't allow you to care for yourself or work.

Treatments may include:

Corticosteroids to help reduce inflammation and relieve symptoms
Other medicines that suppress the immune system (for some severe cases)
Plasmapheresis or plasma exchange to remove antibodies from the blood
Intravenous immune globulin (IVIg), which involves injecting antibodies into the bloodstream to reduce the effect of the antibodies that are causing the problem

Outlook (Prognosis)

The outcome varies. The disorder may continue long term, or you may have repeated episodes of symptoms. Complete recovery is possible, but permanent loss of nerve function is not uncommon.

Possible Complications

Complications of CIDP include:

Pain
Permanent decrease or loss of sensation in areas of the body
Permanent weakness or paralysis in areas of the body
Repeated or unnoticed injury to an area of the body
Side effects of medicines used to treat the disorder

When to Contact a Medical Professional

Contact your provider if you have a loss of movement or sensation in any area of the body, especially if your symptoms get worse.

References

Katirji B. Disorders of peripheral nerves. In: Jankovic J, Mazziotta JC, Pomeroy SL, Newman NJ, eds. Bradley and Daroff's Neurology in Clinical Practice. 8th ed. Philadelphia, PA: Elsevier; 2022:chap 106.

Smith AG, Shy ME. Peripheral neuropathies. In: Goldman L, Cooney KA, eds. Goldman-Cecil Medicine. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 388.

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Review Date: 6/13/2024

Reviewed By: Joseph V. Campellone, MD, Department of Neurology, Cooper Medical School at Rowan University, Camden, NJ. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

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