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Congenital rubella

Rubella on an infa...Rubella on an infant's back
Rubella SyndromeRubella Syndrome

Definition

Congenital rubella is a condition that occurs in an infant whose mother is infected with the virus that causes German measles. Congenital means the condition is present at birth.

Causes

Congenital rubella occurs when the rubella virus in the mother affects the developing baby in the first 3 months of pregnancy. After the fourth month, if the mother has a rubella infection, it is less likely to harm the developing baby.

The number of babies born with this condition is much smaller since the rubella vaccine was developed.

Pregnant women and their unborn babies are at risk if:

They are not vaccinated for rubella
They have not had the disease in the past

Symptoms

Symptoms in the infant may include:

Cloudy corneas or white appearance of pupil
Deafness
Developmental delay
Excessive sleepiness
Irritability
Low birth weight
Below average mental functioning (intellectual disability)
Seizures
Small head size
Skin rash at birth

Exams and Tests

The baby's health care provider will order blood and urine tests to check for the virus.

Treatment

There is no specific treatment for congenital rubella. The treatment is symptom-based.

Outlook (Prognosis)

The outcome for a child with congenital rubella depends on how severe the problems are. Heart defects can often be corrected. Damage to the nervous system is permanent.

Possible Complications

Complications may involve many parts of the body.

EYES:

Clouding of the lens of the eye (cataracts)
Damage to the optic nerve (glaucoma)
Damage to the retina (retinopathy)

HEART:

A blood vessel that usually closes shortly after birth remains open (patent ductus arteriosus)
Narrowing of the large artery that delivers oxygen-rich blood to the heart (pulmonary artery stenosis)
Other heart defects

CENTRAL NERVOUS SYSTEM:

Intellectual disability
Difficulty with physical movement (motor disability)
Small head from poor brain development
Brain infection (encephalitis)
Infection of the spinal column and tissue around the brain (meningitis)

OTHER:

Deafness
Low blood platelet count
Enlarged liver and spleen
Abnormal muscle tone
Bone disease

When to Contact a Medical Professional

Contact your provider if:

You have concerns about congenital rubella.
You are unsure if you have had the rubella vaccine.
You or your children need a rubella vaccine.

Prevention

Vaccination prior to pregnancy can prevent this condition. Pregnant women who have not had the vaccine should avoid contact with people who have the rubella virus.

References

Gershon AA. Rubella virus (German measles). In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 9th ed. Philadelphia, PA: Elsevier; 2020:chap 152.

Mason WH, Gans HA. Rubella. In: Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. Nelson Textbook of Pediatrics. 21st ed. Philadelphia, PA: Elsevier; 2020:chap 274.

Reef SE. Rubella (German measles). In Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier; 2020:chap 344.

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Review Date: 4/28/2023

Reviewed By: Neil K. Kaneshiro, MD, MHA, Clinical Professor of Pediatrics, University of Washington School of Medicine, Seattle, WA. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

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