Serum angiotensin-converting enzyme; SACE DefinitionThe ACE test measures the level of angiotensin-converting enzyme (ACE) in the blood. How the Test is PerformedHow to Prepare for the TestFollow your health care provider's instructions for not eating or drinking for up to 12 hours before the test. If you are on steroid medicine, ask your provider if you need to stop the medicine before the test, because steroids can decrease ACE levels. Do not stop any medicine before talking to your provider. How the Test will FeelWhen the needle is inserted to draw blood, some people feel moderate pain. Others feel only a prick or stinging. Afterward, there may be some throbbing or slight bruising. This soon goes away. Why the Test is PerformedThis test is most often ordered to help diagnose and monitor a disorder called sarcoidosis. People with sarcoidosis may have their ACE level tested regularly to check how severe the disease is and how well treatment is working. This test may also help confirm a diagnosis of Gaucher disease. Normal ResultsNormal values vary based on your age and the test method used. Adults have an ACE level less than 40 micrograms per liter. Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or test different samples. Talk to your provider about the meaning of your specific test results. What Abnormal Results MeanHigher than normal ACE level may be a sign of sarcoidosis. ACE levels may rise or fall as sarcoidosis worsens or improves. A higher than normal ACE level may also be seen in several other diseases and disorders, including:
Lower than normal ACE level may indicate:
RisksThere is little risk involved with having your blood taken. Veins and arteries vary in size from one person to another and from one side of the body to the other. Taking blood from some people may be more difficult than from others. Other risks associated with having blood drawn are slight, but may include:
ReferencesPincus MR, Carty RP. Clinical enzymology. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 24th ed. Philadelphia, PA: Elsevier; 2022:chap 21. Vaidya A, Zennaro MC, Stowasser M. Primary aldosteronism. In: Robertson RP, ed. DeGroot's Endocrinology. 8th ed. Philadelphia, PA: Elsevier; 2023:chap 95. Young WF. Endocrine hypertension. In: Melmed S, Auchus RJ, Goldfine AB, Koenig RJ, Rosen CJ, eds. Williams Textbook of Endocrinology. 14th ed. Philadelphia, PA: Elsevier; 2020:chap 16. | |
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Review Date: 11/19/2023 Reviewed By: Jacob Berman, MD, MPH, Clinical Assistant Professor of Medicine, Division of General Internal Medicine, University of Washington School of Medicine, Seattle, WA. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team. The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. No warranty of any kind, either expressed or implied, is made as to the accuracy, reliability, timeliness, or correctness of any translations made by a third-party service of the information provided herein into any other language. © 1997- A.D.A.M., a business unit of Ebix, Inc. Any duplication or distribution of the information contained herein is strictly prohibited. | |
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Blood test
